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Specifically it blocks a type of serotonin known as 5-HT1A, which is released during sex and tells the body when to release semen.
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GSK's drug works by blocking uptake of serotonin, a chemical involved in mood cognition, reward, learning, memory, and numerous physical processes. The researchers estimate that at a population level, it would make the average man with premature ejaculation last one minute and 40 seconds longer. Results showed those given the 3mg dose lasted 16 per cent longer than the placebo group and those given 7mg lasted 77 per cent longer. They were asked to self-collect a semen sample and show it to an investigator sitting in an adjoining room. The participants were asked to press a pedal at the start of masturbation and then again at the time of ejaculation. They were then shown 10 minutes of pornography that involved vaginal and oral intercourse.Ī signal instructed the subjects to start masturbating and told them to continue doing so until they reached orgasm. To establish a baseline, participants were asked to masturbate about a week before starting the treatment and then again after receiving either a placebo or real pill.ĭuring the masturbation sessions, patients were initially shown 20 minutes of a natural history or geography programme. The study was double blinded, meaning neither the researchers or men knew who was receiving the experimental or dummy drugs. The medicine has not been named yet and is still known as GSK958108. Participants were split into three groups - one given 3mg of the drug, one given 7mg and one given a placebo.